NFL · 2026

San Francisco 49ers

Schedule, closing lines and results against the spread for the 2026 season.

2026 schedule

1. Thu, Sep 10Week 1@ Los Angeles RamsW 27-7Line+3.5WTotal47.5U
2. Sun, Sep 20Week 2vs Miami DolphinsW 35-13Line−12.5WTotal44.5O
3. Sun, Sep 27Week 3vs Arizona CardinalsW 36-30Line−7.5LTotal48.5O
4. Sun, Oct 4Week 4vs Denver BroncosW 24-14Line−3WTotal48.5U
5. Sun, Oct 11Week 5@ Seattle SeahawksW 32-29Line+3WTotal46.5O
6. Mon, Oct 19Week 6vs Washington CommandersLine−7.5Total51.5
7. Sun, Oct 25Week 7@ Atlanta FalconsL 20-29Line−2.5LTotal49.5U
8. Sun, Nov 8Week 9vs Las Vegas RaidersLine−10Total51.5
9. Sun, Nov 15Week 10@ Dallas CowboysLine+1.5Total52.5
10. Sun, Nov 22Week 11vs Minnesota VikingsLine−3.5Total46.5
11. Sun, Nov 29Week 12vs Seattle SeahawksLine+1.5Total46.5
12. Sun, Dec 6Week 13@ New York GiantsLine−3Total47.5
13. Sun, Dec 13Week 14vs Los Angeles RamsLine+2.5Total49.5
14. Thu, Dec 17Week 15@ Los Angeles ChargersLine+2.5Total47.5
15. Sun, Dec 27Week 16@ Kansas City ChiefsLine+3Total46.5
16. Sun, Jan 3Week 17vs Philadelphia EaglesLine−1.5Total45.5
17. Sun, Jan 10Week 18@ Arizona CardinalsLine−8.5Total44.5

Results are graded against the closing line, the last price posted before kickoff. Odds shown for reference only. If gambling stops being fun, call 1-800-GAMBLER.